Trazodone pills for Sleep

Trazodone for Sleep

Is Trazodone a sleeping pill?

Trazodone refers to antidepressants used in various disorders of a depressive nature.

Trazodone 50 mg for sleep

Trazodone removes the following mental manifestations of anxiety:

  • fear;
  • affective tension;
  • irritability;
  • sleep disorders.

In patients, there is a normalization of sleep, reduced painful craving for alcohol.

Trazodone is used for the following types of disorders:

  • bulimia;
  • panic attacks or phobias;
  • benzodiazepine drug dependence;
  • kleptomania;
  • acute manifestations of hangover;
  • pain in diabetic neuropathy;
  • impotence, sexual disorders;
  • as a prophylactic agent for migraine.

If a patient is diagnosed with depression, then the indications for use of the drug are the following manifestations:

  • anxiety;
  • loss of appetite;
  • insomnia;
  • lethargy or agitation;
  • weakness;
  • sexual disorders;
  • suicidal thoughts.

Mode of application

Trazodone is used as directed by the attending physician. The drug is most often administered orally, but sometimes intravenous or intramuscular administration is chosen as an injection. At the beginning of treatment, doctors prescribe no more than 50 milligrams of the drug per day, divided into 2-3 doses. The maximum dosage can not exceed 500 milligrams per day. For intravenous and intramuscular administration, one ampoule is used per injection.

Trazodone 50 mg for sleep

Desyrel (Trazodone) 50 mg is an antidepressant that belongs to the triazolopyridine group. The drug is available in the form of biconvex tablets of prolonged action, white.

A functioning component of the drug is trazodone, which has an anti-depressant effect with a calming and anxiolytic effect.

The active component of trazodone quickly eliminates somatic and mental symptoms, especially effective when sleep is disordered.

Also, Trazodone 50 mg is able to normalize the excited pathetic state, restores potency and improves mood.

When the active substance is applied to the body, emotional tension is eliminated, the feeling of panic disappears, and sleep is accelerated. The drug eliminates symptoms such as headache, tachycardia, myalgia, and signs of aggravated anxiety and anxiety.

As a result of the action of Trazodone 50 mg, normal sleep is restored. With the passage of a therapeutic course stabilization of the emotional state is noted and the craving for alcohol decreases in the presence of withdrawal syndrome.

Trazodone dosage for sleep

Trazodone tablets for sleep are prescribed for internal use, 30 minutes before a meal, or four hours after a meal.

Trazodone tablets for sleep is recommended to use without chewing. The course of treatment must begin with a dose of 50-100 mg at a time. This amount should be consumed during the first three days of the therapeutic course.

Starting from the fourth day, the dose should be increased to 150 milligrams per day. Next, the amount of medication should be increased by 50 mg per day, until the desired therapeutic dose is established.

In general, the total daily amount of the drug should not exceed 150 mg at a time. Drug use patterns differ according to the age category of patients:

Age 18 years. The daily dose of Trazodone for sleep is calculated in the amount of 1-2 mg per body weight. The set amount is divided into several stages. If necessary, the daily amount of the drug can be gradually increased every three days to a total dose of 6 mg per 1 kg of weight.

Elderly and debilitated patients. The course of therapy for this category of patients begins with a dose of 100 mg per day. Next, the amount of the drug rises to a total daily dose of 300 mg.

During pregnancy and during breastfeeding, the drug Trazodone is not recommended for use. Patients with impaired kidney and liver drug is prescribed with extreme caution. Trazodone is also not prescribed in children (up to six years). During the course of treatment with this drug is not recommended to use alcohol.

How fast does Trazodone work?

Trazodone has a high level of absorption from the gastrointestinal tract. Simultaneous use of the drug with food inhibits absorption time.

The maximum accumulation of constituents of the drug Trazodone in the blood plasma is noted 1-2 hours after its internal administration. The ability to switch components of the drug and plasma proteins is 90-95%. The active ingredient Trazodone is able to penetrate granulocytic barriers and can pass into breast milk.

The metabolic process takes place in the liver, followed by release of the active metabolite, chlorophenylpiperazine. The half-life of the drug Trazodone is 3-6 hours. A significant amount of anthrol is excreted by the kidneys (75%). Full output is stopped after 98 hours after consuming the drug. About twenty percent of the drug is excreted in the bile.

Trazodone for insomnia

Chronic insomnia diagnosed in at least one third of the US adult population is one of the most common and costly diseases. The Association of Psychiatrists of America defines insomnia as difficulty in falling asleep (sleep latency), sleep disturbances accompanied by frequent arousals, insufficient duration and poor quality of sleep.


Patients with a chronic form of insomnia are often susceptible to depression, and depression may develop as a result of insomnia, or be independent of it. Therefore, despite the lack of FDA approval, doctors use sedative antidepressants to treat insomnia. Trazodone, an antidepressant for the triazolopyridine group, gives a sedative effect and is often prescribed to treat insomnia.

The recommended dose of trazodone for insomnia is ≤ 100 mg. Acceptance of trazodone 75-500 mg per day can have negative consequences in the form of obscure vision, constipation, dizziness, drowsiness, dry mouth, headaches, hypotension, nausea and vomiting. Patients and patients with diagnosed cardiovascular disease should take trazodone with caution.

Trazodone: mechanism of action

The active substance of the drug mainly has antidepressant activity and a weak anxiolytic and sedative effect. Trazodone does not affect MAO (monoamine oxidase). In this way, it differs from antidepressants of the tricyclic type and MAO inhibiting agents.

Pharmacodynamics is based on a high level of affinity for a number of serotonin receptors that agonistically or antagonistically interact with the active component of the medication in question.

Trazodone shows a high level of efficacy in patients with depression and sleep disorders. The drug increases the duration and depth of sleep, as well as normalizes its quality.

Pharmacokinetics of the drug involves its absorption from the gastrointestinal tract after 4-5 hours. The half-life is 1.5 hours. Basically, the drug is excreted in the urine.

Another name for Trazodone

Trazodone has been marketed under a large number of brand names throughout the world. Major brand names include Desyrel (worldwide), Molipaxin (Ireland, United Kingdom), Oleptro (United States), Trazorel (Canada), and Trittico (worldwide). (Source: Wikipedia)

Can you take Trazodone while pregnant?

Do not take Trazodone during pregnancy and lactation!

Does Trazodone cause nightmares?

Trazodone does not cause nightmares. This drug is used to treat and get rid of such conditions.

Prazozin is often used to get rid of post-traumatic nightmares, but some studies show that nightmares may resume after the abolition of this drug. If at the same time with nightmares a person suffers from anxiety disorder or depression, then such a group of antidepressants such as SSRIs (for example, fluoxetine, sertraline and paroxetine) should be used as the first line.

Among other things, medications such as Trazodone, Nefazodone, and atypical neuroleptins (risperidone, olanzapine, and quetiapine) have a moderately positive effect in treating nightmares.

Does Trazodone help with sleep?

The effect of Trazodone on the sleep structure was determined using polysomnographic methods of research in patients with depression and in patients suffering from insomnia for other reasons.

The effect of long-term treatment with trazodone on the nature (patterns) of sleep in patients with depression has been studied extensively. From the moment of the start of treatment, an effect similar to a sleeping pill was observed, namely: the duration of sleep increased as a whole and the second phase of sleep in particular, and the latent phase of sleep was reduced and the rates of nighttime awakenings decreased.

It was recently confirmed that depression patients who took 100 mg of trazodone per night had sleep rates (compared with placebo) as follows: sleep efficiency increased, total time and total sleep period and duration of slow-sleep phase (SWS) increased, in particular , and also the frequency / duration of wakefulness was reduced at night and in the early morning hours.

The specified effect of trazodone on sleep suggests that the drug is best used in the treatment of patients with depression, insomnia.

Trazodone is also an effective hypnotic for patients suffering from insomnia caused by antidepressants of other classes. This was confirmed in a study of depression patients who had insomnia when taking Fluoxetine or Bupropion.