Effexor XR Venlafaxine Information

Effexor XR (Venlafaxine) treatment

The use of tricyclic antidepressants in pain syndromes is limited because of the numerous side effects such as sedation, cognitive disturbances, orthostatic hypotension, cardiac rhythm disturbances, dry mouth, constipation, due to the affinity of tricyclic antidepressants for muscarinic, cholinergic, histamine and a1-adrenoceptor .

Venlafaxine capsulesThe drug Effexor XR (Venlafaxine) as tricyclic antidepressants inhibit the reuptake of serotonin and norepinephrine, but has a more favorable safety profile, as it has no affinity for muscarinic, cholinergic, histamine and a1-adrenoceptor. Effexor XR (Venlafaxine) has demonstrated its effectiveness and safety in several animal models, healthy volunteers and patients with various pain syndromes.

The study E. Lang et al. use of venlafaxine has reduced manifestations of hyperalgesia induced by surgical sciatic nerve compression. The effect was observed as in the prophylactic receiving Effexor XR (Venlafaxine) (before surgery) and during the application of venlafaxine after surgery, i.e. after the development of neuropathic damage. In another study a single dose of venlafaxine had no effect on normal rats, whereas the increase in the pain threshold was observed in models of chronic sciatic nerve compression. In studies with multiple receiving venlafaxine efficacy was demonstrated in healthy rats and rats with chronic sciatic nerve compression. These effects are suppressed by a-methyl-p-tyrosine (inhibitor of norepinephrine synthesis) and parahlorfenilalaninom (serotonin synthesis inhibitor) but not naloxone (opioid antagonist), indicating a specific mechanism of action of Effexor XR (Venlafaxine) is not associated with opioid neurotransmitter systems.

You may read: How to get out of depression yourself: advice of a psychotherapist

The study of venlafaxine with painful diabetic neuropathy were randomly assigned 244 patients without depression who received venlafaxine-XR 75 mg / day (81 patients), 150-225 mg / day (82 patients) or placebo (81 patients) for up to 6 weeks. Patients included in the study experienced daily pain of moderate or severe intensity (VAS) at least for 3 months prior to study. Patients treated with venlafaxine-XR at a dose of 150-225 mg / day showed a significantly greater reduction in pain intensity for 3-6 th weeks of treatment compared to placebo and to the 5-6 th weeks of treatment compared with patients receiving 75 mg / day. The most significant improvement was noted in the 6th week of treatment. This fact indicates that for the adequate evaluation of the effectiveness of analgesic is needed venlafaxine 6-week course of treatment.

The most common side effect in this study was nausea, which was shown in 5% of patients in the placebo group, 22% – in the group of patients treated with 75 mg of venlafaxine and 10% of patients treated with 150-225 mg of venlafaxine. The output from the study due to side effects was 4, 7 and 10%, respectively, in the placebo group taking 75 mg and 150-250 mg of venlafaxine.

Effexor XR (Venlafaxine) 150mg, 75mg and 37.5mg – Effects of treatment

Venlafaxine is a reuptake inhibitor of serotonin and norepinephrine. By their mechanism provides relief of neuropathic pain. Venlafaxine does not bind to muscarine-cholinergic, histamine and a1-adrenergic receptors, so that when his appointment is possible to avoid many of the adverse events, developing the application of tricyclic antidepressants.

Clinical studies suggest that the use of venlafaxine is a good method for the treatment of patients with chronic pain syndromes within major depression or generalized anxiety disorder. This is important because more than 40% of patients with major depressive disorder have at least one symptom of pain (headache, back pain, joint pain, pain in the limbs, or pain in the gastrointestinal tract). The use of venlafaxine and reduces the level of depression and the severity of painful symptoms.

Venlafaxine-XR is indicated for major depression, generalized anxiety and social anxiety disorder at doses ranging from 75 to 225 mg / day. For some patients may be effective in low doses of venlafaxine. Treatment can be started at 37.5 mg / day with gradual increase in the dose for 4-7 days to 75 mg / day.

Studies have shown that the analgesic effect of venlafaxine is caused by mechanisms unrelated to depression. Therefore venlafaxine it proved to be effective and in pain syndromes are not associated with depression and anxiety. While reading the destination of venlafaxine in patients with chronic pain are not yet included in the instructions for its use, the available data indicate that the majority of pain syndromes effective dose is 75-225 mg / day. Data from the randomized, controlled trials have shown that the pain relief occurs within 1-2 weeks after starting treatment. Nevertheless, some patients required a 6-week course of treatment to analgesic effect of venlafaxine became apparent.

Buy generic effexor online

Effexor XR 150 mg prices

Package Per pill Price Savings
See All dosages and prices at official pharmacy
30 pills $1.75 $52.56
60 pills $1.32 $79.32 $25.80
90 pills $1.18 $106.08 $51.60
120 pills $1.11 $132.83 $77.41
360 pills $0.96 $346.90 $283.82

Effexor XR 75 mg prices

Package Per pill Price Savings
See All dosages and prices at official pharmacy
30 pills $1.59 $47.55
60 pills $1.15 $69.16 $25.94
90 pills $1.01 $90.78 $51.87
120 pills $0.94 $112.39 $77.81
360 pills $0.79 $285.30 $285.30

Effexor XR 37.5 mg prices

Package Per pill Price Savings
See All dosages and prices at official pharmacy
60 pills $0.98 $58.69
90 pills $0.86 $77.03 $44.02
180 pills $0.73 $132.05 $110.05
360 pills $0.67 $242.10 $242.10